An article published in The Journal of Urology suggested that in patients with bladder cancer, smoking status is associated with lower neoadjuvant chemotherapy response rates and higher overall and cancer specific mortality, as well as bladder cancer recurrence after radial cystectomy.1
Given these findings, researchers indicated that preoperative counseling, coupled with tightened follow-up, may have a pivotal role in improving the smoking-related long-term survival outcomes in patients with bladder cancer.
This study is important because while it is known that tobacco smoking is the leading cause of bladder cancer, this is the first study to suggest that smoking puts bladder cancer patients at risk after diagnosis, lead authorGiovanni Cacciamani, MD, assistant professor of research urology at theKeck School of Medicine of USC, said in a press release.2
In this study, researchers systematically searched PubMed, MEDLINE, Embase, and Cochrane Library databases for original articles published before April 2019. Overall, 649 articles were identified, and 17 studies were selected that addressed the impact of smoking status on survival outcomes in 13,777 patients after radical cystectomy for bladder cancer.
The primary end points for the study were neoadjuvant chemotherapy response, overall and cancer specific mortality, and recurrence-free survival after radical cystectomy.
A pooled meta-analysis found that active smokers ...