Men on active surveillance for prostate cancer may benefit from adherence to Mediterranean diet principles, according to results of a study conducted by investigators from the University of Texas MD Anderson Cancer Center, Houston.
The research, which was presented during the 2020 European Association of Urology Virtual Congress,1 evaluated Gleason grade group progression in men with newly diagnosed localized prostate cancer enrolled in a prospective active surveillance trial. A Mediterranean diet score (MDS) was calculated for each participant who completed a baseline food frequency questionnaire, and the population was divided into tertiles based on the MDS. A higher MDS reflects greater adherence to the Mediterranean dietary pattern.
During a median follow-up of 36 months, 76 men (18.5%) progressed. Results from a Cox proportional hazards model controlling for clinical characteristics showed that the MDS was modestly associated with time to grade group progression, reported Justin Gregg, MD, assistant professor of urology at The University of Texas MD Anderson Cancer Center.
Compared with the reference group of men in the lowest MDS tertile, there was little difference in risk of progression over time for men with a middle range MDS (hazard ratio [HR] and 95% confidence interval [CI]: 1.02 [0.61-1.70]; P =0.93). Higher MDS adherence ...