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Saturated fat intake leads to cellular reprogramming associated with prostate cancer progression and lethality, according to new research.

These findings could help in identifying patients at higher risk of a more aggressive, lethal disease. In addition, they suggest that dietary intervention involving the reduction of animal fat, and specifically saturated fat consumption in men with early-stage prostate cancer[1], could possibly diminish or delay the risk of disease progression.

Some genescalled oncogenesplay a role in cancer initiation and progression. MYC is one of those.

In this paper, we showed that by mimicking a MYC overexpression, saturated fat intake[2] makes prostate cancer worse, says David P. Labb, assistant professor in the surgery department of the urology division at McGill University.

MYC overexpression profoundly rewires cellular programs and bolsters a distinctive transcriptional signature. MYC is a key factor in tumorigenesis, i.e., it induces malignant properties in normal cells and fuels the growth of cancer cells, adds Labb, who is also a scientist at the Research Institute of the McGill University Health ...

News source: GOOGLE NEWS

See also: The Robotic Urologist