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Saturated fat intake leads to cellular reprogramming associated with prostate cancer progression and lethality, according to new research.
These findings could help in identifying patients at higher risk of a more aggressive, lethal disease. In addition, they suggest that dietary intervention involving the reduction of animal fat, and specifically saturated fat consumption in men with early-stage prostate cancer, could possibly diminish or delay the risk of disease progression.
Some genescalled oncogenesplay a role in cancer initiation and progression. MYC is one of those.
In this paper, we showed that by mimicking a MYC overexpression, saturated fat intake makes prostate cancer worse, says David P. Labb, assistant professor in the surgery department of the urology division at McGill University.
MYC overexpression profoundly rewires cellular programs and bolsters a distinctive transcriptional signature. MYC is a key factor in tumorigenesis, i.e., it induces malignant properties in normal cells and fuels the growth of cancer cells, adds Labb, who is also a scientist at the Research Institute of the McGill University Health ...